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Title: | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape | Authors: | Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa |
Keywords: | glycosylation zinc phthalocyanine photodynamic therapy gold nanoparticles |
Issue Date: | 5-Oct-2018 | Publisher: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | Series/Report no.: | Vol.203 , 85 - 95; | Abstract: | In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-assembly. The conjugates of complex 3 (with both gold nanorods (AuNR) and nanospheres (AuNS)), displayed decreased fluorescence quantum yield with corresponding improved triplet and singlet quantum yields compared to complex 3 alone, however 3-AuNR showed improved properties than 3-AuNS. Complex 3 showed relatively low in vitro dark cytotoxicity against the epithelial breast cancer cells with cell survival ≥ 85% at concentration ≤ 160 μg/mL but afforded reduced photodynamic therapy activity which may be due to aggregation. 3-AuNR afforded superior PDT activity with <50% viable cells at concentration ≥ 40 μg/mL in comparison to 3-AuNS with <50% viable cells at concentration ≥ 80 μg/mL. The superior activity of 3-AuNR is attributed to the photothermal therapy effect since nanorods absorb more light at 680 nm than nanospheres. | URI: | https://www.sciencedirect.com/science/article/abs/pii/S1386142518304815 http://hdl.handle.net/11408/3850 |
Appears in Collections: | Research Papers |
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Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy_ Effect of nanoparticle shape.pdf | Full Text | 3.28 MB | Adobe PDF | ![]() View/Open |
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